It is present in . 4. This blend is suitable for wide pH range (3-8) and heat stable up to 80C. Poloxamer 407: White, prilled or cast solid. National Institutes of Health. both pg and vg are organic compounds of the family of polyfunctional alcohols, commonly used as drug solubilizers in topical, oral, inhaled, nasal, optical and intravenous medications, as well as. As the alkyl chain length increases, water solubility decreases. a. Water solubility Not applicable Solubility in other solvents Not applicable Partition coefficient: n-octanol/water Not applicable . Propylparaben 94-13-3 X Propylene Glycol 57-55-6 X Glycerin 56-81-5 X Sorbitol Solution Mixture X Xanthan Gum 11138-66-2 X Calcium Saccharin 6381-91-5 X . If you would like to learn more about who buys, is looking for, imports, requests, consumes or needs Propylene Glycol (and) DMDM Hydantoin (and) Methylparaben (and) Propylparaben or similar products, the following is a list of some potential buyers of Propylene Glycol (and) DMDM Hydantoin (and) Methylparaben (and) Propylparaben or similar selections: Pharmaceutical Codex: "Soluble, at 20 o, in 70 parts of water, in 7 parts of alcohol, in 13 parts of acetone, in 40 parts of glycerol and in 9 parts of propylene glycol" - Could use propylene glycol as co-solvent - To dissolve 0.6 g need 5.4 ml propylene glycol Ethanol in liquid preparations intended for children It was concluded that the cosolvent propylene glycol is at least of equal preservative importance than both parabens. These compounds and their salts are used mainly for their antifungal and antibacterial properties. Description and solubility: See Chapter 15, Pharmaceutical Solvents and Solubilizing Agents. Glycerin, Magnesium Hydroxide, Methylparaben, Propylparaben, Propylene Glycol, Sodium Saccharin and Sucrose . Analytical Methods The importance of the cosolvent propylene glycol on the antimicrobial preservative efficacy of a pharmaceutical formulation by DOE-ruggedness testing. Glycols Propylene Glycol Soluble Alkyl Sulfates Sodium Lauryl Sulfate Compatible Quaternized Compounds Dicetyl Dimethyl Ammonium Chloride 851. Generally the concentration for antibacterial activity is low (near 0,1%) at such concentration it is soluble in water but to avoid precipitation of this alcaline compound the pH of the medium. Ingredients: Propylene glycol, diazolidinyl urea, methylparaben, propylparaben This water-soluble liquid preservative is effective against Gram-positive bacteria, Gram-negative bacteria, yeast, mold, and spores. Germaben II-E is a solubilized combination of Germall II with methylparaben and propylparaben in propylene glycol. FD&C Yellow #6, glycerin, methylparaben, natural/artificial orange flavor, propylene glycol, propylparaben, purified water, sucralose, trisodium citrate dihydrate. Some of these functions are: Not for use in lip products. Propylene Glycol is also used to . A short summary of this paper. Competitor D: commercially available blend containing 70% Phenoxyethanol + 15% Methyl- . Propylene Glycol (and) Diazolidinyl Urea (and) Methylparaben (and) Propylparaben. Back. Propylene glycol ( IUPAC name: propane-1,2-diol) is a viscous, colorless liquid, which is nearly odorless but possesses a faintly sweet taste. Caprylyl Glycol [emollient base]; Sorbic Acid **Paraben FREE Does NOT release formaldehyde : Clear Liquid : Works best at a pH of 6.0 or less water soluble : 95 degrees f or below: 0.75 - 1.5% : Phenopip : Phenoxyethanol; Methylparaben Ethylparaben; Butylparaben; Propylparaben; Isobutylparaben : Clear Liquid : Ph 3.0 - 8.0 oil / water soluble . It is one of the most widely used ingredients in cosmetics and personal care products. Water-soluble ointment (polyethylene glycol ointment, USP 14) Polyethylene glycol 4000 (Carbowax 4000) 50%. Comes as white, dry powder. The solubility of metronidazole was 1g/100mL, and we only made 100 mL. 4063-1) fluorouracil on a weight/weight basis compounded with edetate disodium, hydroxypropyl cellulose, methylparaben, propylene glycol, propylparaben, water and tromethamine. Propylene glycol (1, 2- propanediol) is an organic compound (a diol alcohol) and is a tasteless, odorless and colorless clear oily liquid. Background. 17 The World Health Organization recommends a daily maximal intake of propylene glycol within food additives of 0.025 g/kg 18; nephrotoxicity . It is miscible with propylene glycol and glycerin. Perfect for leave-on products containing a water phase, such as lotions, creams, water-based serums . Sodium Propylparaben . Very slightly soluble in water; freely soluble in alcohol and in ether; slightly soluble in boiling water. polysorbate 60, propylene glycol, propylparaben, purified water, stearyl alcohol, and white petrolatum. Propylene glycol is a versatile substance and carries out many functions in the product formulations its included in. These findings were confirmed by taking the pharmacopoeial criteria as the evaluation basis, where the dominant influence of propylene glycol concentration is apparent. Propylparaben occurs as a colourless powder or crystalline, odourless, and tasteless powder. 2. Phenoxyethanol and Methylparaben and Ethylparaben and Propylparaben and Butylparaben and Isobutylparaben. Phenoxyethanol is stable up to 85C (185F)and is soluble in most oils. The molecular weight of 5-fluorouracil is 130.08 and the structural formula is: . Propylene glycol 10.0 ml clear, hygroscopic liquid miscible with water inhibitor of mold growth; solubilization agent Methylparaben 100 mg white crystalline needles 1 g/400 ml water; 1 g/ 70 ml warm glycerol preservative Propylparaben 50 mg white crystal soluble in 2000 parts water antifungal, preservative It is also soluble in water from 0.5 to 2.67 grams per 100 grams of water. Preservative efficacy is also improved by the addition of propylene glycol (2-5%), or by using parabens in combination with other antimicrobial agents such as imidurea; . Albuterol sulfate is a white crystalline powder, soluble in water and slightly soluble in ethanol. . Solubility: Methyl Paraben is easily soluble in diethyl ether, . 1 Solubility data for compounds that ordinarily are liquids at 25 are expressed in terms of the ratio of the volume of solute to the volume of solvent; i.e., 1 mL dissolved in mL of solvent. Technical support (855) 874 4100 X. Propylparaben | C10H12O3 | CID 7175 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. col. a solvent for several water-insoluble drugs intended for parenteral administration; an ingredient of hydrophilic ointment; a viscous organic solvent frequently used in pharmaceutical preparations to dissolve drug substances with limited aqueous solubility; used in part for preparing injectable solutions of diazepam . /HUMAN EXPOSURE STUDIES/ Methylparaben, ethylparaben, propylparaben, and butylparaben were each applied to the backs of 50 humans at concentrations of 5, 7, 10, 12, and 15% in propylene glycol. . propylene glycol, propylparaben, purified water, stearyl alcohol, and white petrolatum. 854. It is a white to practically white crystalline powder which is sparingly soluble . This Paper. Publication types Comparative Study Mix ingredients of Phase C together and adjust pH to 7.0 with KOH (10% solution). It is a complete broad spectrum antimicrobial preservative system that is effective against Gram-positive and Gram-negative . 6 (-)--Bisabolol (levomenol, C 15 H 26 O, MW 222.4) is a sesquiterpene isolated from the volatile oil of chamomile. Recommended dose: 0.3-1%. It is readily soluble at a level of 1.0% in both water/oil and oil/water emulsions, but not in water alone. It is in anywhere from 26.4% to 37.8% of registered personal care products. Solubility Water approx. PH: Use in products with a PH of between 3-7.5. H,3 H)-pyrimidinedione. While some investigators believe parabens to have a definite taste at the concentrations used, other sources disagree. Highly soluble in cold water. Its chemical formula is CH 3 CH (OH)CH 2 OH. PubChem . Parabens are often used in combination for best results Poor aqueous solubility; increased by alcohol or propylene glycol May contain sodium hydroxide and/or hydrochloric acid to adjust . Suitable for use in water in oil and oil in water emulsions, as well as fully water-based products. 3. Propylene Glycol and Polypropylene Glycols attract water and function as moisturizers to enhance the appearance of skin by reducing flaking and restoring suppleness. Propylparaben: Small, colorless crystals or white powder. Parabens display a low irritation potential, have low toxicity levels, and are The synthetic black food coloring on the other hand, is obtained by combining FD . Brand Names. This level provides to the product: 0.30% Germall II, 0.11% methylparaben, 0.03% propylparaben and 0.56% propylene glycol. Propylparaben has been reported to be very slightly soluble in water, but freely soluble in alcohol and ether [ 1, 3 ]. Containing two alcohol groups, it is classed as a diol. Tubes of 15 and 50 g. Ointment: Each g contains: 0.5 mg (0.05%) of betamethasone (as dipropionate . Water solubility Not applicable Solubility in other solvents Not applicable Partition coefficient: n-octanol/water A synthetic liquid substance that absorbs water, propylene glycol classified by the chemical formula C3H8O2. Freely soluble in water; sparingly soluble in alcohol; insoluble in fixed oils. It has a variety of uses beyond being a food additive . Propylparaben is Propyl 4-hydroxybenzoate, a member of a family of alky esters of para-hydroxybenzoic acid differing by their chemical substituents on the benzene ring. Add mixture from Step (1) into Step (2) mixture using vigorous agitation and continue mixing while cooling to 45C. 2in the propylene minutes, and the approximate retention times for the 3 isomers ofglycol by dividing the area under the propylene glycol peak by the dipropylene glycol, when present, are 8.2, 9.0, and 10.2 minutes,sum of the areas under all of the peaks, excluding those due to air respectively. PROPYLENE GLYCOL. The synthetic yellow pigment too contains propylparaben, propylene glycol and water, along with FD&C yellow 5 (tartrazine) and FD&C red 40. Is odorless and hygroscopic. methylparaben, propylparaben, edetate disodium, sodium chloride, polysorbate 80, aroma . FD&C Yellow No. Parabens (methyl paraben, propyl paraben) are widely used as preservatives by pharmaceutical and cosmetic industries. propylene glycol and slightly soluble or almost insoluble in water. DrugBank Accession Number. Due to its ingredients, it is not lip or eye safe. Freely soluble in water and in alcohol; sparingly soluble in propylene glycol. Propylparaben Sodium: White powder. 2 Liquid phase only; silicon dioxide remains as a residue in these solvents. Propylene glycol is a colorless, nearly odorless, thick liquid. CAS 5026-62-. Polyethylene glycols ointment Melt the stearyl alcohol and white petrolatum and warm to about 75C.Heat the water to 75C and add the sodium lauryl sulfate, propylene glycol, methylparaben, and propylparaben.Add the aqueous phase and stir until congealed. National Library of Medicine. Item Number: 470076 CAS Number: 78491-02-8, Mixture Formula: N/A UPI Tradename: Uniben IIE Mfr: Tradename: GERMABEN II-E. Lawrence Tsen. Heatto75C. It is a whit e to practically white crystalline powder which is sparingly soluble in water and slightly soluble in alcohol. Anesthesia & Analgesia, 2010. Mix ingredients of Phase A together and heat to 85C. propylene glycol, propylene glycol monostearate, propylparaben and purified water. This blend is suitable for wide pH range (3-8) and heat stable up to 80C. Propylene glycol is a commonly found ingredient in cosmetic, personal, and skin care products. Propylene glycol: inhibitor of mold growth; solubilizing agent Methylparaben: preservative Propylparaben: anti-fungal, preservative (soluble in 2000 parts water) Purified Water: solvent This product is an example of a saturated solution. IV. Propylene glycol. Propylene Glycol is an organic alcohol. Test compounds were applied daily for 5 days, and patches were then removed and the sites scored. Shampoos and liquid soaps generally require less than 1.0% Germaben II. While some investigators believe parabens to have a definite taste at the concentrations used, other sources disagree. 6. . Customer service (855) 874 4100 X. 8. 5. The maximal clearance rate of propylene glycol in humans with normal renal and hepatic function is not known, although extrapolation of murine data suggests a metabolic capacity of >1 g/d in a 70-kg man. Energetics of the molecular interactions of L-cysteine, L-serine, and L-asparagine in aqueous propylene glycol solutions at 298.15 K Integral enthalpies of dissolution Delta(sol) H (m) of L-cysteine, L-serine, and L-asparagine in aqueous solutions of 1,3-propylene glycol at organic solvent concentrations of up to 0.26 mole fraction are . The solubilities of propylparaben in various solvents are shown in Table 3 [ 5, 6 ], and the solubilities of propylparaben in water at 25C as a single component and in mixtures with other parabens are shown in Table 4 [ 7, 8 ]. A clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations. The alphabetical handbook of 250 excipients (40 more than the last edition) features a 2-4 page section for each excipient that includes nonproprietary names, synonyms, chemical name and CAS registry number, empirical formula and molecular weight, structural formula, functional category, applications in pharmaceutical formulation or technology, description, pharmacopeial specifications . 0.6. glycerin, 2.5. REFERENCES . b. (~.~~-~~) Table 1 summarizes other physicochemical properties of the Parabens. Safety Data Sheet : Issuing date: 03/09/2015 : Revision date: 03/09/2015 : Revision number: 00 : EINECS: The high cost of parabens limits their applications in food products. One gram of fluorouracil is soluble in 100 mL of propylene glycol. Phototoxicity: Non-phototoxic (Propylparaben) Phototoxicity: Non-phototoxic. 0.6. glycerin, 2.5. Propylparaben (propyl hydroxybenzoate, propyl parahydroxybenzoate, C 10 H 12 O 3 9 . . (Methylparaben) Subchronic Oral Toxicity: Rats fed diets containing 0-50,000 ppm of Propylene Glycol for 15 weeks. 1 Solubility data for compounds that ordinarily are liquids at 25 are expressed in terms of the ratio of the volume of solute to the volume of solvent; i.e., 1 mL dissolved in mL of solvent. ( 1) Another name for it is "propane-1,2-diol," which is sometimes used when listing it as a . The high cost of parabens limits their applications in food products. 12 CLINICAL PHARMACOLOGY DB01839. Full PDF Package Download Full PDF Package. Read Paper. The gel may also comprise preservatives and a solvent and have a pH of between 6.5 and 7.5. It is soluble in water and slightly soluble in alcohol. It is freely soluble in ethanol, methanol, fixed oils, and liquid paraffin. 2 Liquid phase only; silicon dioxide remains as a residue in these solvents. EFUDEX Cream contains 5% fluorouracil in a vanishing cream base consisting of methylparaben, polysorbate 60, propylene glycol, propylparaben, purified water, stearyl alcohol, and white petrolatum. 1. Cimetidine hydrochloride is freely soluble in water, soluble in alcohol, very slightly soluble in chloroform and practically insoluble in ether. Page 11 Zinc Sulfate. It is practically insoluble in water, glycerin, propylene glycol, solutions of alkali hydroxides, and dilute aqueous mineral acids. Propylene glycol | C3H8O2 | CID 1030 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety . Add Phase B into Phase A. and water, and multiplying by 100. Formaldehyde Free Solubility - Water insoluble (0.50), Ethanol -Miscible, Isopropanol miscible, Propylene Glycol miscible, Isopropyl Myristate Miscible,Glycerin 10 %, Triethanolamine- Miscible, Polysorbate- 80 Miscible Helpful info Phenonip can withstand higher temperatures than many preservatives, up to up to 176 F. Phenonip can be used up to . In this study, both a 2% and a 5% concentration of propylene glycol allowed the minimum inhibitory concentration of methylparaben to be reduced from 0.18% to 0.1% when combined with 0.02% propylparaben . Propylparaben 94-13-3 Butylparaben 94-26-6 Appearance White, dry powder Solubility Soluble in propylene glycol, phenoxyethanol, ethanol etc., limited solubility in water Parabens are the most commonly used preservatives in personal care products.
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